New Study of 17,000 Human Traits — and 100% of Them Are Heritable
From the “Discussion” section of the study:
WE HAVE conducted a meta-analysis of virtually all twin studies published in the past 50 years, on a wide range of traits and reporting on more than 14 million twin pairs across 39 different countries. Our results provide compelling evidence that all human traits are heritable: not one trait had a weighted heritability estimate of zero.
The relative influences of genes and environment are not randomly distributed across all traits but cluster in functional domains. In general, we showed that reported estimates of variance components from model-fitting can underestimate the true trait heritability, when compared with heritability based on twin correlations. Roughly two-thirds of traits show a pattern of monozygotic and dizygotic twin correlations that is consistent with a simple model whereby trait resemblance is solely due to additive genetic variation. This implies that, for the majority of complex traits, causal genetic variants can be detected using a simple additive genetic model.
Meta-Analysis of the Heritability of Human Traits Based on Fifty Years of Twin Studies
Despite a century of research on complex traits in humans, the relative importance and specific nature of the influences of genes and environment on human traits remain controversial. We report a meta-analysis of twin correlations and reported variance components for 17,804 traits from 2,748 publications including 14,558,903 partly dependent twin pairs, virtually all published twin studies of complex traits. Estimates of heritability cluster strongly within functional domains, and across all traits the reported heritability is 49%. For a majority (69%) of traits, the observed twin correlations are consistent with a simple and parsimonious model where twin resemblance is solely due to additive genetic variation. The data are inconsistent with substantial influences from shared environment or non-additive genetic variation. This study provides the most comprehensive analysis of the causes of individual differences in human traits thus far and will guide future gene-mapping efforts. All the results can be visualized using the MaTCH webtool.
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Source: Study Alert
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